Clinical and pharmacological differences in early‐ versus late‐onset Parkinson's disease
Identifieur interne : 002049 ( Main/Exploration ); précédent : 002048; suivant : 002050Clinical and pharmacological differences in early‐ versus late‐onset Parkinson's disease
Auteurs : G. Gomez Arevalo [Argentine] ; R. Jorge [Argentine] ; S. Garcia [Argentine] ; O. Scipioni [Argentine] ; Gershanik [Argentine]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-05.
English descriptors
Abstract
We evaluated whether patients with early‐onset Parkinson's disease (EOPD) have a different clinical profile and pharmacological response than those with late‐onset disease (LOPD). We performed a retrospective analysis and an acute pharmacological challenge with L‐Dopa in 34 EOPD (age at onset between 21 and 40 years) and 34 LOPD (onset after age 60) patients. All patients complete a structured questionnaire cross‐checked against mediacal record charts and underwent an acute levodopa test. Most significant differences were in the mode of onset, time to diagnosis, and degree of initial improvement. We did not observe differences with regard to motor fluctuations. The acute levodopa test showed no differences in latency to response onset between groups. However, the magnitude of the response was greater and the duration shorter in EOPD patients. Younger patients had greater reductions in bradykinesia scores, whereas posture/gait symptomatology was less responsive in older patients. The type and severity of dyskinesias also differed significantly between groups. Our findings suggest that central pharmacokinetics, pharmacodynamics, and, possibly, nondopaminergic systems play a role in the age‐related differences observed in Parkinson's disease.
Url:
DOI: 10.1002/mds.870120303
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical and pharmacological differences in early‐ versus late‐onset Parkinson's disease</title>
<author><name sortKey="Arevalo, G Gomez" sort="Arevalo, G Gomez" uniqKey="Arevalo G" first="G. Gomez" last="Arevalo">G. Gomez Arevalo</name>
</author>
<author><name sortKey="Jorge, R" sort="Jorge, R" uniqKey="Jorge R" first="R." last="Jorge">R. Jorge</name>
</author>
<author><name sortKey="Garcia, S" sort="Garcia, S" uniqKey="Garcia S" first="S." last="Garcia">S. Garcia</name>
</author>
<author><name sortKey="Scipioni, O" sort="Scipioni, O" uniqKey="Scipioni O" first="O." last="Scipioni">O. Scipioni</name>
</author>
<author><name sortKey="Gershanik" sort="Gershanik" uniqKey="Gershanik" last="Gershanik">Gershanik</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A86E2C1CED791B14CE040FEFBF97A56A2D3469F8</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1002/mds.870120303</idno>
<idno type="url">https://api.istex.fr/document/A86E2C1CED791B14CE040FEFBF97A56A2D3469F8/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002015</idno>
<idno type="wicri:Area/Main/Curation">001D17</idno>
<idno type="wicri:Area/Main/Exploration">002049</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Clinical and pharmacological differences in early‐ versus late‐onset Parkinson's disease</title>
<author><name sortKey="Arevalo, G Gomez" sort="Arevalo, G Gomez" uniqKey="Arevalo G" first="G. Gomez" last="Arevalo">G. Gomez Arevalo</name>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Seccion Enfermedades Extrapiramidales, Centro Neurologico, Hospital Frances, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jorge, R" sort="Jorge, R" uniqKey="Jorge R" first="R." last="Jorge">R. Jorge</name>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Seccion Enfermedades Extrapiramidales, Centro Neurologico, Hospital Frances, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Current Address: Servicio de Neurologia, Hospital de Clinicas “Jose de San Martin,” Buenos Aires</wicri:regionArea>
<wicri:noRegion>” Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia, S" sort="Garcia, S" uniqKey="Garcia S" first="S." last="Garcia">S. Garcia</name>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Seccion Enfermedades Extrapiramidales, Centro Neurologico, Hospital Frances, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scipioni, O" sort="Scipioni, O" uniqKey="Scipioni O" first="O." last="Scipioni">O. Scipioni</name>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Seccion Enfermedades Extrapiramidales, Centro Neurologico, Hospital Frances, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gershanik" sort="Gershanik" uniqKey="Gershanik" last="Gershanik">Gershanik</name>
<affiliation wicri:level="1"><country xml:lang="fr">Argentine</country>
<wicri:regionArea>Seccion Enfermedades Extrapiramidales, Centro Neurologico, Hospital Frances, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1997-05">1997-05</date>
<biblScope unit="volume">12</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="277">277</biblScope>
<biblScope unit="page" to="284">284</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A86E2C1CED791B14CE040FEFBF97A56A2D3469F8</idno>
<idno type="DOI">10.1002/mds.870120303</idno>
<idno type="ArticleID">MDS870120303</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute levodopa test</term>
<term>Early onset</term>
<term>Levodopa therapy</term>
<term>Parkinson's disease</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We evaluated whether patients with early‐onset Parkinson's disease (EOPD) have a different clinical profile and pharmacological response than those with late‐onset disease (LOPD). We performed a retrospective analysis and an acute pharmacological challenge with L‐Dopa in 34 EOPD (age at onset between 21 and 40 years) and 34 LOPD (onset after age 60) patients. All patients complete a structured questionnaire cross‐checked against mediacal record charts and underwent an acute levodopa test. Most significant differences were in the mode of onset, time to diagnosis, and degree of initial improvement. We did not observe differences with regard to motor fluctuations. The acute levodopa test showed no differences in latency to response onset between groups. However, the magnitude of the response was greater and the duration shorter in EOPD patients. Younger patients had greater reductions in bradykinesia scores, whereas posture/gait symptomatology was less responsive in older patients. The type and severity of dyskinesias also differed significantly between groups. Our findings suggest that central pharmacokinetics, pharmacodynamics, and, possibly, nondopaminergic systems play a role in the age‐related differences observed in Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Argentine</li>
</country>
</list>
<tree><country name="Argentine"><noRegion><name sortKey="Arevalo, G Gomez" sort="Arevalo, G Gomez" uniqKey="Arevalo G" first="G. Gomez" last="Arevalo">G. Gomez Arevalo</name>
</noRegion>
<name sortKey="Garcia, S" sort="Garcia, S" uniqKey="Garcia S" first="S." last="Garcia">S. Garcia</name>
<name sortKey="Gershanik" sort="Gershanik" uniqKey="Gershanik" last="Gershanik">Gershanik</name>
<name sortKey="Jorge, R" sort="Jorge, R" uniqKey="Jorge R" first="R." last="Jorge">R. Jorge</name>
<name sortKey="Jorge, R" sort="Jorge, R" uniqKey="Jorge R" first="R." last="Jorge">R. Jorge</name>
<name sortKey="Scipioni, O" sort="Scipioni, O" uniqKey="Scipioni O" first="O." last="Scipioni">O. Scipioni</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002049 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002049 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:A86E2C1CED791B14CE040FEFBF97A56A2D3469F8 |texte= Clinical and pharmacological differences in early‐ versus late‐onset Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |